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After the initial 4 months, a subset of participants (270) continued the treatment for an additional 449 months in a single-blind extension phase focused on weight maintenance
Diabetes Care, 27(11), 2628-2635
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Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis
Although GLP-1RAs exert beneficial effects by delaying gastric emptying, enhancing satiety, and reducing caloric intakemechanisms that predominantly promote FM reductionthey are also associated with a loss of lean mass, particularly in the context of substantial weight loss where muscle preservation is critical for metabolic health [77]
