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The inability to sustain weight loss may be due to PYY 3-36 -induced Y2-R down-regulation and tolerance (i.e., tachyphylaxis) and/or activation of compensatory mechanisms in response to reduced food intake

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Exercise may enhance GLP-1 response to meals, though evidence remains mixed

While this represents a significant improvement over many traditional frozen meals, it often falls at the lower end of the 30g+ protein threshold recommended by dietitians for optimal muscle preservation in GLP-1 users

Our lab has tested these extensively, and our findings are quite clear