Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12
utilizing these values can also help distinguish B12 deficiency from folate deficiency (with folate deficiency, MMA will be normal and homocysteine will be elevated) (6) Levels less than 200 pg/mL are considered deficient (2) Once deficiency is confirmed, it is important to address underlying etiology
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Wei C, Kim IK, Li L, Wu L, Gupta S
Vitamin B12 in health and disease
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