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The clinic's preference is to taper rather than stop abruptly, and to plan the off-ramp with the same care as the on-ramp

With rising concentrations of KA, the K m values of the monophenolase activity increased and the V max values decreased, an indication of a mixed mode of inhibition, with an inhibition constant K I of 1.1 M and K IS of 61 M

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doi:10.1074/jbc.M202773200