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An experimental model of GLP-1R knockout mice (GLP-1R-/-) [37] demonstrated that (GLP-1R-/-) mice exhibited only modest decreases in gonadal weight, while females exhibited delayed puberty, but subsequent fertility and sex-steroid secretion were normal

But recent studies have also suggested semaglutide and other GLP-1 receptor agonists might have anti-inflammatory properties, and could even protect against cartilage wear and tear

Its common adverse reactions are similar to other GLP-1 drugs, primarily consisting of gastrointestinal issues (nausea, diarrhea, vomiting, etc.), which are mostly mild to moderate and typically decrease over time

Clinical Diabetes: A Publication of the American Diabetes Association, 38 (4), 390402