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The FDA-approved prescribing information recommends rotating injection sites with each dose to reduce the risk of lipodystrophy and injection site reactions

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Euglycemic diabetic ketoacidosis is another concern that may delay initiation or result in early discontinuation of SGLT2i therapy [4, 19]

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This inhibitor is chemically a cyanopyrrolidide compound which by itself is a substrate for DPP-4 with a slow dissociation rate which enables it to function as a competitive inhibitor of the enzyme (Figure 2 shows the results in these studies

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