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For the FOXO4-DRI treatment group, 50 M FOXO4-DRI (MCE, HY-P4157) was added to the glucose-free DMEM (Gibco, Catalog #11966-025) medium, followed by 3 h of oxygen-glucose deprivation (OGD) treatment
But low toxicity doesnt mean zero things to think about. First, carboxypeptidases will tear this peptide apart fast
Safety and considerations There is not enough high-quality, modern human safety data to make broad safety claims about DSIP, and that uncertainty is itself part of the clinical picture
Procedures like microneedling, subcision, and laser have stronger evidence for structural acne scars
The appeal is mechanistic