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Theres no single winner

There arent powerful aggressive mechanics like Exert or strong tribal themes like Merfolk

One of the rarest and most valuable Pokemon Pikachu Illustrator cards is up for sale on eBay, and that too for a whopping $100,000

Drawing three cards as an instant for a single blue mana is so ridiculous that nothing even remotely close to this card has been attempted again in Magic

Therefore, this card is this expensive because of how popular Iono is, instead of how playable she is (but, of course, it can also be interesting in alternative lists!)

I think mutate is a little too complex for most players